Enhanced efficacy of histone deacetylase inhibitor combined with bromodomain inhibitor in glioblastoma
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چکیده
منابع مشابه
The Bromodomain Inhibitor JQ1 and the Histone Deacetylase Inhibitor Panobinostat Synergistically Reduce N-Myc Expression and Induce Anticancer Effects.
PURPOSE Patients with neuroblastoma associated with MYCN oncogene amplification experience a very poor prognosis. BET bromodomain inhibitors are among the most promising novel anticancer agents as they block BRD3 and BRD4 from activating oncogene transcription. However, treatment with BET bromodomain inhibitors alone does not result in cancer remission in many murine models. EXPERIMENTAL DESI...
متن کاملRadiosensitization of glioblastoma cells using a histone deacetylase inhibitor (SAHA) comparing carbon ions with X-rays.
PURPOSE Prognosis for patients with glioblastoma (GBM) remains poor, and new treatments are needed. Here we used a combination of two novel treatment modalities: Carbon ions and a histone deacetylase inhibitor (HDACi). We compared these to conventional X-rays, measuring the increased effectiveness of carbon ions as well as radiosensitization using HDACi. MATERIALS AND METHODS Suberoylanilide ...
متن کاملRadiosensitisation of glioblastoma cells using a histone deacetylase inhibitor (SAHA) comparing carbon ions with X-rays
Short running title: HDAC inhibition with low and high LET radiation Abstract Purpose: Prognosis for patients with glioblastoma (GBM) remains poor, and new treatments are needed. Here we use a combination of two novel treatment modalities, carbon ions and a histone deacetylase inhibitor (HDACi). We compare these to conventional X-rays, measuring the increased effectiveness of carbon ions as wel...
متن کاملHybrid Polar Histone Deacetylase Inhibitor Induces Apoptosis
Inhibitors of histone deacetylase (HDAC) have been shown to have both apoptotic and differentiating effects on various tumor cells. M-carboxycinnamic acid bishydroxamide (CBHA) is a recently developed hybrid polar compound structurally related to hexamethylene bisacetamide. CBHA is a potent inhibitor of HDAC activity. CBHA induces cellular growth arrest and differentiation in model tumor system...
متن کاملBiomarkers of Histone Deacetylase Inhibitor Activity in a Phase 1 Combined-Modality Study with Radiotherapy
BACKGROUND Following the demonstration that histone deacetylase inhibitors enhanced experimental radiation-induced clonogenic suppression, the Pelvic Radiation and Vorinostat (PRAVO) phase 1 study, combining fractionated radiotherapy with daily vorinostat for pelvic carcinoma, was designed to evaluate both clinical and novel biomarker endpoints, the latter relating to pharmacodynamic indicators...
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ژورنال
عنوان ژورنال: Journal of Experimental & Clinical Cancer Research
سال: 2018
ISSN: 1756-9966
DOI: 10.1186/s13046-018-0916-y